News: Latest – distributed around Yorkshire August 12, 2016 12:14:49 PM
New research from the University of Dundee, and funded by Arthritis Research UK and the MRC, has shown that targeting a specific group of enzymes could be a viable strategy for treating autoimmune diseases such as psoriasis and multiple sclerosis, which affect millions of people.
Autoimmune diseases develop when the immune system, which defends the body against disease, is convinced that our healthy cells are foreign. As a result, the immune system then attacks the healthy cells.
Researchers led by Dr Simon Arthur in the School of Life Sciences at Dundee examined the way that a drug called dimethylfumarate (DMF), which is licensed in the UK as Tecfidera, works. DMF is primarily used to treat multiple sclerosis but has also been shown to be an effective treatment for psoriasis, both of which are autoimmune diseases.
The team found that DMF is effective because it blocks the action of a particular group of enzymes called E2s, some of which are active in inducing inflammation.
“This is significant because previously the pharmaceutical industry has been sceptical lupus about the viability of targeting these enzymes as a means of treating diseases,” said Dr Vicky McGuire, lead author on the study.
“We have found that DMF is actually already targeting these enzymes with very positive results. This follows on from previous research from the University’s School of Life Sciences that showed that another drug, BAY 11-7082 also works by inhibiting E2 enzymes. However, unlike BAY 11-7082, DMF is approved for clinical use.”
Dr Arthur added, “This suggests that more selective inhibitors of E2’s may be well tolerated and validates these enzymes as targets for future drug development.”
Dr Stephen Simpson, director of research and programmes at the charity Arthritis Research UK, said he was excited by the results of the study they cofounded.
“Autoimmune conditions such as rheumatoid arthritis, lupus and psoriatic arthritis can have a devastating impact on people’s lives, causing extreme pain and fatigue that can make even everyday tasks incredibly difficult,” he said. “We welcome this research in helping identify pathways in these types of conditions that may offer targets for new and effective treatment”
The results of the research are published in Nature’s Scientific Reports.
- Doncaster assault- do you recognise this man?
- Witness appeal following sexual assault, Sheffield
- Waterstones Glassworks Wath-upon-Dearne
- High Street Wath 1950
- Cudworth community comes together following collision
- River Dove wetland projects will support wildlife and reduce flood risk
- Very Vintage Evening
- Wath Grammar School Prefects 1948
- Halifax in Yorkshire
- Lost Lander Finally Spotted on Comet’s Surface
- Students engineer driverless cars as part of a new society
- Barnsley Sixth Form College celebrates 99% pass rate
- Gene Responsible for Down Syndrome
- Young people’s jobs boost
- University Centre Rotherham Appoints Contractor Willmott Dixon
- Dog walker assaulted in Barnsley – did you see what happened?
- WANTED MAN! Aaron Divers?
- Man charged with string of burglaries in Doncaster
- Violent offender jailed for five years following Sheffield street robbery
- Dearne and Dove Canal Wath
- Invest in your future!
- Grab a slice of family fun this summer
- Rotherham Show returns for its 38th year
- Barnsley parents urged to fill out survey regarding 30 hours free childcare plans
- Bank Street Mexborough South Yorkshire
- Celebrating their last Carol Service – Wath Main Miners
- Experience Park Life at Cannon Hall
- Doncaster burglar behind bars
- Wath Railway Station 1974
- The Manvers Wath-upon-Dearne
- Barnsley ram raids
- Virtual reality for children in care support
- It’s not too late to study at UCB this September
- Crime prevention advice issued following Sheffield burglaries.
- Public Space Protection Order (PSPO) Rotherham Town Centre and Clifton Park
- Barnsley man jailed for ‘violent’ robbery
- Jailed for sexually abusing young girl
- Students experience life on the watch
- West Melton – Herbert Needham