News: Latest – distributed around Yorkshire August 12, 2016 12:14:49 PM
New research from the University of Dundee, and funded by Arthritis Research UK and the MRC, has shown that targeting a specific group of enzymes could be a viable strategy for treating autoimmune diseases such as psoriasis and multiple sclerosis, which affect millions of people.
Autoimmune diseases develop when the immune system, which defends the body against disease, is convinced that our healthy cells are foreign. As a result, the immune system then attacks the healthy cells.
Researchers led by Dr Simon Arthur in the School of Life Sciences at Dundee examined the way that a drug called dimethylfumarate (DMF), which is licensed in the UK as Tecfidera, works. DMF is primarily used to treat multiple sclerosis but has also been shown to be an effective treatment for psoriasis, both of which are autoimmune diseases.
The team found that DMF is effective because it blocks the action of a particular group of enzymes called E2s, some of which are active in inducing inflammation.
“This is significant because previously the pharmaceutical industry has been sceptical lupus about the viability of targeting these enzymes as a means of treating diseases,” said Dr Vicky McGuire, lead author on the study.
“We have found that DMF is actually already targeting these enzymes with very positive results. This follows on from previous research from the University’s School of Life Sciences that showed that another drug, BAY 11-7082 also works by inhibiting E2 enzymes. However, unlike BAY 11-7082, DMF is approved for clinical use.”
Dr Arthur added, “This suggests that more selective inhibitors of E2’s may be well tolerated and validates these enzymes as targets for future drug development.”
Dr Stephen Simpson, director of research and programmes at the charity Arthritis Research UK, said he was excited by the results of the study they cofounded.
“Autoimmune conditions such as rheumatoid arthritis, lupus and psoriatic arthritis can have a devastating impact on people’s lives, causing extreme pain and fatigue that can make even everyday tasks incredibly difficult,” he said. “We welcome this research in helping identify pathways in these types of conditions that may offer targets for new and effective treatment”
The results of the research are published in Nature’s Scientific Reports.
- Spiral Snowflake Galaxy
- £20k drugs haul lands Doncaster man behind bars for six years
- Rotherham man guilty of grooming teenager
- Get your treasures valued at Clifton Park Museum
- Man charged in connection to Sheffield murder investigation
- Virtual reality for children in care support
- Guide your career
- Stopped. Searched. Shamed.
- Yorkshire Show 1902
- Rotherham trio wanted for crystal meth conviction
- Barnsley Sixth Form College celebrates 99% pass rate
- Are You #AlrightPal?
- More Barnsley families on their way to getting five a day
- Rare book relating to pit ponies
- Halifax in Yorkshire
- Praise for polar bear conservation efforts
- Doncaster drugs den discovered
- Cooper Gallery become winners of prestigious Sandford Award
- Readers Group at Wath-upon-Dearne
- Decade behind bars for armed robber
- Sheffield man jailed for numerous sexual offences
- Statement on the outcome of misconduct in public office trial
- New Barnsley Market Food Hall looking for fresh food traders
- West Melton In South Yorkshire
- Wath All Saints Church
- Young people’s jobs boost
- Forge Island footbridge works completed ahead of schedule
- It’s never too late to learn
- Clues For How Giant Black Holes Form
- Bank Street Mexborough South Yorkshire
- Six men charged in connection to burglaries and robbery
- Denaby Crossing
- Experience Park Life at Cannon Hall
- Doncaster assault- do you recognise this man?
- Homes that repair themselves
- Flame of Hope in Rotherham for 2017 Special Olympics Torch Run
- Did NASA ever go to the moon?
- Adrian Pogmore sentenced to 12 months’ imprisonment
- NASA Extends Hubble Space Telescope Science Operations Contract
- Refurbished play area opens in Wath